Which gene is associated with the regulation of serotonin and may indirectly influence aggressive behavior?

The MAOA gene, known as the monoamine oxidase A gene, plays a significant role in the breakdown of neurotransmitters, including serotonin. Serotonin is a key neurotransmitter linked with mood regulation and impulse control. Variations in the MAOA gene can lead to differences in serotonin levels, which in turn can influence behaviors, including aggression.

Research has shown that individuals with low-activity variants of the MAOA gene may have an increased risk of exhibiting aggressive behavior, especially when combined with adverse environmental factors such as childhood trauma. This connection highlights how genetic predispositions can interact with environmental influences to shape behavior, particularly in the context of aggression. Understanding the role of the MAOA gene provides insight into the biological underpinnings of behavior, demonstrating a clear link between genetics, neurotransmitter regulation, and psychosocial outcomes.